Rasgrf2

RasGRF2, also known as Ras-GRF2 or Ras guanine nucleotide releasing factor 2, is a protein encoded by the Rasgrf2 gene. This gene is found in humans and other mammals. RasGRF2 belongs to a family of guanine nucleotide exchange factors (GEFs) that play a crucial role in cellular signaling pathways. Specifically, it facilitates the exchange of GDP for GTP on Ras proteins, thereby activating them.

The Ras GTPases are central regulators of numerous cellular processes including cell growth, differentiation, and survival. RasGRF2 is known to interact with and activate specific Ras isoforms. Its activity is modulated by various stimuli, and it is involved in diverse cellular functions. Research has indicated that RasGRF2 plays a role in neuronal development and function, contributing to processes like neurite outgrowth and synaptic plasticity. It has also been implicated in other physiological processes, though its precise functions are still being actively investigated. Aberrant RasGRF2 activity has been linked to certain diseases, highlighting its importance in maintaining cellular homeostasis. The complex regulatory mechanisms and downstream effects of RasGRF2 continue to be a focus of scientific inquiry.