Rab3mediated
Rab3-mediated refers to cellular processes governed by the Rab3 subfamily of small GTPases, which regulate regulated exocytosis and vesicle trafficking in neurons and secretory cells. The Rab3 family includes Rab3A, Rab3B, Rab3C, and Rab3D. These proteins localize primarily to secretory vesicles and cycle between an inactive GDP-bound state and an active GTP-bound state. Activation and inactivation are controlled by guanine nucleotide exchange factors (GEFs) that promote GDP-to-GTP exchange, and GTPase-activating proteins (GAPs) that accelerate GTP hydrolysis. Rab3GAP1/2 and GRAB are examples of such regulators in vertebrates.
Active Rab3-GTP engages effector proteins, notably Rabphilin-3A and the Rab3-interacting molecules (RIM1 and RIM2), which link
In neurons, Rab3 is enriched on synaptic vesicles and participates in presynaptic vesicle cycling and neurotransmitter
Rab3-mediated pathways are studied to understand the mechanisms of synaptic transmission and hormone release, and altered