Rab3interacting
Rab3interacting is a descriptor used in molecular biology to refer to proteins that bind the Rab3 family of small GTPases and influence vesicular trafficking, particularly in secretory pathways. The term most often appears in reference to the Rab3-interacting molecule family, abbreviated as RIM, which includes proteins such as RIM1 and RIM2.
RIM proteins are presynaptic scaffolding components that organize the active zone where neurotransmitter release occurs. They
Genes encoding RIM1 and RIM2 are expressed predominantly in neurons, with higher levels in presynaptic terminals.
Beyond the RIM subfamily, other Rab3-interacting proteins exist, including Rab3IP (Rab3-interacting protein), which can modulate Rab3