RAASaktiivisuus

RAASaktiivisuus refers to the activity of the Renin-Angiotensin-Aldosterone System (RAAS). This is a complex hormonal cascade that plays a crucial role in regulating blood pressure, fluid balance, and electrolyte levels in the body. The system is initiated when the kidneys detect a drop in blood pressure or blood volume, or a decrease in sodium levels.

In response, the kidneys release an enzyme called renin. Renin then acts on angiotensinogen, a protein produced by the liver, to form angiotensin I. This intermediate molecule is then converted to angiotensin II by an enzyme called angiotensin-converting enzyme (ACE), which is found primarily in the lungs.

Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, which increases blood pressure. It also stimulates the adrenal glands to release aldosterone. Aldosterone, a hormone, acts on the kidneys to increase the reabsorption of sodium and water, further contributing to increased blood volume and pressure. The RAAS also influences thirst, encouraging fluid intake.

Dysregulation of RAASaktiivisuus is implicated in various cardiovascular and renal diseases. Conditions like hypertension (high blood pressure), heart failure, and kidney disease are often associated with an overactive RAAS. Conversely, underactivity can also have implications. Medications targeting the RAAS, such as ACE inhibitors and angiotensin II receptor blockers (ARBs), are widely used to manage these conditions by blocking the actions of key components within the system.