Pusterytme

Pusterytme is a hypothetical dermatological syndrome defined by recurrent pustular eruptions on an erythematous base. The term merges pustule formation with erythema and is occasionally invoked in speculative medical literature as a composite description of neutrophilic dermatoses.

Clinical features include sudden onset of sterile pustules on a reddened skin surface, often concentrated on the trunk and proximal limbs. Lesions may merge into larger plaques, with mild itch or burning and variable fever during flares.

The underlying causes are not established. Proposed mechanisms include dysregulated neutrophil recruitment, epidermal barrier disruption, and environmental or medication triggers in susceptible individuals. Some discussions emphasize a potential genetic predisposition in sparse case reports.

Diagnosis relies on history and examination, supported by histopathology showing subcorneal or intraepidermal neutrophilic pustules. Laboratory tests may show elevated inflammatory markers; cultures are typically negative for primary infection but may reveal secondary colonization. Differential diagnoses include pustular psoriasis, AGEP, and bacterial folliculitis.

Treatment is guided by severity and may include potent topical corticosteroids, calcineurin inhibitors, and systemic therapies such as short courses of corticosteroids or immunomodulators in persistent cases. Antibiotics are used if secondary infection is suspected. The course is often relapsing, but many cases respond to therapy.

Pusterytme is not widely recognized as a real medical entity; it appears in fictional or theoretical contexts as a teaching construct to discuss pustular dermatoses.