Peptidesidos
Peptidesidos are a recently identified group of short peptide molecules that have been isolated from certain Gram‑negative bacteria and some eukaryotic tissues. The name derives from the combination of “peptide” with the suffix “‑idos,” which is used in biochemical nomenclature to denote a specific structural motif characterized by a cyclic backbone and an appended hydrophobic tail. Unlike classical signaling peptides that typically act through G‑protein coupled receptors, peptidesidos have been shown to interact directly with membrane lipid bilayers, inducing localized curvature and facilitating endocytosis of certain protein cargoes.
Structural studies using NMR spectroscopy have revealed that peptidesidos generally consist of 8–12 amino acid residues
Functional assays in cell culture have demonstrated that peptidesidos can enhance the uptake of macromolecules such