Paucigranulocytic

Paucigranulocytic is an adjective used in medicine to describe tissue or inflammatory sites that contain a very low number of granulocytes, the white blood cells that include neutrophils, eosinophils, and basophils. The term is derived from Latin roots meaning “few” and “granulocyte.” It is used as a descriptive pattern in pathology, immunology, and related clinical fields, often in contrast to granulocytic patterns where granulocytes are abundant.

In the context of airway disease, paucigranulocytic refers to an inflammatory phenotype in which sputum or bronchial samples show low levels of granulocytes, particularly eosinophils and neutrophils. This pattern is discussed in research on asthma and is part of a broader framework that also includes eosinilic, neutrophilic, and mixed granulocytic phenotypes. Paucigranulocytic asthma, for example, lacks the abundant granulocyte infiltration seen in other asthma subtypes and may have distinct clinical characteristics or treatment responses.

The term is also used in chronic rhinosinusitis and other mucosal inflammatory conditions to describe biopsies or secretions with few granulocytes, suggesting a non-granulocytic inflammatory milieu. Because granulocyte counts can vary with sampling methods and thresholds, classifications labeled as paucigranulocytic are often context-dependent and primarily descriptive rather than diagnostic of a single disease.

Overall, paucigranulocytic serves as a concise descriptor for low granulocyte presence in inflammatory tissue, helping to categorize inflammatory patterns across conditions while acknowledging variability in measurement and interpretation.