Participialin
Participialin is a protein that plays a crucial role in the regulation of cell division and differentiation in various organisms, including humans. It is a member of the E3 ubiquitin ligase family, which are enzymes that attach ubiquitin molecules to target proteins, marking them for degradation by the proteasome. Participialin specifically targets the retinoblastoma protein (Rb) for ubiquitination and subsequent degradation, thereby releasing the E2F transcription factors that are essential for cell cycle progression and DNA synthesis.
The name "participialin" is derived from the Latin word "participare," meaning "to share," reflecting its role
Participialin's function is tightly regulated by various factors, including the p53 tumor suppressor protein and the