Pagets

Pagets is a surname of English origin. The name appears in various contexts, most notably in medicine, where several conditions are named after Sir James Paget, a 19th‑century English surgeon.

Paget's disease of bone, also called osteitis deformans, is a chronic disorder of bone remodeling. It features excessive osteoclast-mediated bone resorption followed by disorganized osteoblastic bone formation, producing structurally abnormal bone that thickens and enlarges. It most commonly affects the pelvis, skull, spine, and long bones. Patients may experience bone pain, deformity, arthritis, or fractures; some are asymptomatic and diagnosed incidentally via radiographs or elevated alkaline phosphatase. Management focuses on slowing bone turnover with bisphosphonates, with calcitonin as an alternative, and treatment of symptoms and complications.

Paget's disease of the nipple, or Paget's disease of the breast, is a rare form of skin cancer involving the skin of the nipple and areola, usually associated with an underlying ductal breast carcinoma. Symptoms include persistent itching, redness, flaking or crusting of the nipple, sometimes with discharge. Diagnosis is by biopsy. Treatment targets the underlying breast cancer and may include surgery, radiation therapy, chemotherapy, or hormonal therapy, depending on disease extent. Prognosis depends on the extent of underlying cancer.

The surname Paget has historical associations with figures in science and medicine, most prominently Sir James Paget, whose namesake conditions are still discussed in medical literature today.