PLATdomaincontaining
PLAT domain-containing refers to a broad family of proteins that harbor the PLAT domain, a lipid-binding fold named after Polycystin-1, Lipoxygenase, and Alpha-toxin. The domain is typically about 100–120 amino acids in length and forms a conserved beta-sandwich structure that can interact with lipid membranes. PLAT domains appear in a wide range of proteins, either as a solitary module or appended to other catalytic or regulatory regions, and they are found from bacteria to humans.
Function and localization: The primary role of the PLAT domain is to mediate association with lipid membranes
Distribution and diversity: Across species, PLAT domain-containing proteins form a diverse set that includes extracellular, secreted,
Clinical and research notes: Because of its membrane-binding properties, the PLAT domain is of interest in studies