PINK1Parkin
PINK1Parkin is a protein that plays a crucial role in maintaining cellular health and protecting against oxidative stress. It is a member of the E3 ubiquitin ligase family, which are enzymes that attach ubiquitin molecules to target proteins, marking them for degradation by the proteasome. PINK1Parkin is composed of two distinct domains: the PINK1 domain, which is responsible for its mitochondrial localization, and the Parkin domain, which is the ubiquitin ligase activity.
PINK1Parkin is primarily known for its role in the mitochondrial quality control pathway. Under normal conditions,
Mutations in the PINK1Parkin gene have been linked to several neurodegenerative diseases, including Parkinson's disease, which