PEX7n

PEX7n is a designation used in some genomic and proteomic databases to refer to a gene or transcript that is related to PEX7, the peroxisomal targeting signal 2 (PTS2) receptor. The available information is fragmented and there is no consensus on whether PEX7n represents a distinct, functional gene, a splice variant of PEX7, or a pseudogene. Because of inconsistent annotation across databases and species, PEX7n is often treated as provisional or of uncertain coding potential.

Functional characterization: There are no peer-reviewed studies definitively demonstrating expression, subcellular localization, or biochemical activity for PEX7n. In silico analyses, when present, may predict short open reading frames or conserved domains related to peroxisome biology, but such predictions require experimental validation. Accordingly, no robust role in peroxisomal protein import or disease has been established for PEX7n.

Genomic context: PEX7n entries frequently arise in the context of broader PEX7 family analyses or as alternative transcripts in certain species. Some annotations suggest a nonfunctional remnant rather than a conserved protein-coding gene, supporting a pseudogene interpretation in some lineages.

Status and usage: Researchers should treat PEX7n as provisional. Confirmations require independent validation, including transcript evidence, proteomics, and functional assays.

See also: PEX7; peroxisome; peroxisomal targeting signals; peroxisome biogenesis.