PEX11sarja

PEX11sarja refers to a family of peroxisomal membrane proteins that play a crucial role in peroxisome dynamics, specifically in the process of peroxisome fission. These proteins are integral membrane proteins found in the membrane of peroxisomes. The PEX11 family is conserved across a wide range of eukaryotic organisms, from yeast to humans, indicating its fundamental importance in cellular function.

The primary function attributed to PEX11sarja proteins is the initiation and promotion of peroxisome division. They are thought to act as key regulators of membrane curvature and elongation, events that precede the physical splitting of a peroxisome into two smaller ones. PEX11 proteins can form distinct structures within the peroxisomal membrane, and their activity is often regulated by post-translational modifications and interactions with other peroxisomal proteins.

Dysfunction or mutations in PEX11 genes have been linked to various peroxisome-related disorders in humans, collectively known as peroxisome biogenesis disorders (PBDs). These disorders can manifest with a range of severe developmental and neurological abnormalities, highlighting the critical role of proper peroxisome function for overall health. Research into PEX11sarja continues to unravel the intricate mechanisms governing peroxisome maintenance and division, offering potential avenues for therapeutic interventions in related diseases.