PDHkompleksi
PDHkompleksi, or the pyruvate dehydrogenase complex, is a mitochondrial multi-enzyme assembly that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, providing the acetyl group that enters the citric acid cycle. It thereby links glycolysis in the cytosol to aerobic respiration in mitochondria and plays a central role in cellular energy production.
The complex consists of three catalytic components: E1 (pyruvate dehydrogenase), E2 (dihydrolipoyl transacetylase) and E3 (dihydrolipoamide
Regulation of PDHkompleksi is primarily through reversible phosphorylation. PDH kinase (PDK) inactivates E1 by phosphorylation, while
Genetic defects in PDHkompleksi or its regulatory enzymes cause pyruvate dehydrogenase deficiency, a metabolic disorder marked