PDE10B

Phosphodiesterase 10B, also known as PDE10B, is an enzyme encoded by the PDE10B gene in humans. It belongs to the phosphodiesterase (PDE) superfamily, a group of enzymes that hydrolyze cyclic nucleotides, specifically cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE10B is a dual-specificity phosphodiesterase, meaning it can degrade both cAMP and cGMP.

The PDE10B enzyme is primarily expressed in the brain, particularly in the striatum, a region involved in motor control, reward, and habit formation. Its specific localization suggests a role in regulating neuronal signaling pathways within these brain regions. PDE10B is believed to play a crucial role in modulating the activity of dopaminergic and glutamatergic neurotransmission, which are important for various brain functions.

Research into PDE10B has focused on its potential as a therapeutic target for neurological and psychiatric disorders. Dysregulation of cyclic nucleotide signaling has been implicated in conditions such as schizophrenia, Huntington's disease, and Parkinson's disease. Inhibiting PDE10B activity could potentially restore normal cyclic nucleotide levels and alleviate symptoms associated with these disorders. However, the development of selective PDE10B inhibitors is an ongoing area of research.