PDE10A

PDE10A is a phosphodiesterase enzyme encoded by the PDE10A gene in humans. Phosphodiesterases are a large family of enzymes that regulate intracellular levels of cyclic nucleotides, specifically cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE10A is unique in its ability to hydrolyze both cAMP and cGMP. It is predominantly expressed in the brain, with particularly high levels found in the striatum and nucleus accumbens, regions associated with reward, motivation, and motor control. Its presence in these key areas suggests a significant role in neuronal signaling and function. Research has indicated that PDE10A is involved in the regulation of dopamine signaling pathways, as well as other neurotransmitter systems. Dysregulation of PDE10A activity has been implicated in various neurological and psychiatric disorders, including schizophrenia, Huntington's disease, and Parkinson's disease. Consequently, PDE10A has emerged as a potential therapeutic target for these conditions, and inhibitors of PDE10A are currently being investigated for their potential clinical benefits.