PBPKmodelleerimine

PBPKmodelleerimine refers to Physiologically Based Pharmacokinetic modeling. It is a computational technique used to predict the absorption, distribution, metabolism, and excretion (ADME) of chemical substances within a biological system. Unlike traditional empirical models, PBPK models are built upon physiological and biochemical data. They represent the body as a system of interconnected compartments, each corresponding to specific organs or tissues. Within these compartments, parameters describe physiological factors such as blood flow rates, tissue volumes, and enzyme activities.

The process involves integrating data on the chemical's physicochemical properties, such as solubility and lipophilicity, with the physiological parameters. This allows for the simulation of how a substance will behave in the body over time after administration. PBPK models can be used to extrapolate pharmacokinetic data across different species, populations (e.g., children, pregnant women), and exposure routes. They are valuable tools in drug development, risk assessment of environmental contaminants, and regulatory science. By providing a mechanistic understanding of ADME processes, PBPKmodelleerimine helps to reduce the need for extensive animal testing and can inform decision-making regarding chemical safety and efficacy.