PAK4

PAK4, also known as p21-activated kinase 4, is a serine/threonine kinase that plays a role in various cellular processes. It is a member of the p21-activated kinase (PAK) family, which are downstream effectors of the Rho family of GTPases. PAK4 is involved in regulating cell morphology, migration, proliferation, and survival. Its activity is controlled by its association with GTP-bound Cdc42, a Rho family GTPase.

The gene encoding PAK4 is located on chromosome 19 in humans. PAK4 has been implicated in the development and progression of several diseases, particularly cancer. It is often overexpressed in various types of tumors and has been shown to promote tumor growth, invasion, and metastasis. PAK4's role in cancer is multifaceted, involving the regulation of cell cycle progression, inhibition of apoptosis, and promotion of angiogenesis.

Research into PAK4 has identified it as a potential therapeutic target. Inhibitors of PAK4 are being investigated for their ability to suppress cancer cell growth and improve treatment outcomes. Beyond cancer, PAK4 has also been linked to other cellular functions and potential disease mechanisms, though research in these areas is ongoing. Its involvement in cytoskeletal organization and cell signaling makes it a significant player in cellular dynamics.