Orthoacetocumene

Orthoacetocumene, also known as 1-(2-isopropylphenyl)ethanone or 2-isopropylacetophenone, is an organic compound with the chemical formula C11H14O. It is a substituted acetophenone where an isopropyl group is attached to the ortho position of the phenyl ring. This compound is a colorless to pale yellow liquid with a characteristic aromatic odor.

The synthesis of orthoacetocumene can be achieved through various methods, including Friedel-Crafts acylation of cumene (isopropylbenzene) with acetyl chloride or acetic anhydride in the presence of a Lewis acid catalyst such as aluminum chloride. Other synthetic routes may involve the oxidation of appropriate precursors.

Orthoacetocumene finds limited direct applications in industry. However, it serves as an intermediate in the synthesis of more complex organic molecules. Its chemical structure, featuring both a ketone and an isopropyl group on an aromatic ring, makes it a versatile building block for pharmaceutical compounds, agrochemicals, and fine chemicals. Research into its properties and potential derivatives continues to explore its utility in various chemical processes. The compound's reactivity is influenced by both the electrophilic carbonyl group and the steric hindrance introduced by the ortho-isopropyl substituent.