Organonachip

Organonachip is a microphysiological system in which living human cells are cultured within microfluidic devices to mimic organ-level functions. Building on the organ-on-a-chip concept, organonachip aims to reproduce the physiology, morphology and interactive tissue interfaces of specific organs more faithfully than traditional cell culture.

Organonachip devices combine microfluidic channels, cell culture chambers and extracellular matrix components. They use materials such as PDMS, glass or plastics and include integrated sensors for real-time readouts. Mechanical cues such as fluid shear, cyclic stretch and peristaltic motion are applied to emulate breathing, blood flow or gut motility, enabling realistic tissue behavior.

Applications of organonachip span drug development, toxicology and disease modeling, with examples including lung-on-a-chip, gut-on-a-chip and liver-on-a-chip platforms. Some systems connect multiple organ modules to form a body-on-a-chip, enabling pharmacokinetic studies and systemic responses. Researchers also explore patient-specific cells for personalized medicine.

Challenges include technical complexity, variability and limited standardization, which hinder replication and regulatory qualification. Validation against human data is ongoing, with emphasis on reproducibility, scalability and integration with computational models. Despite these hurdles, organonachip is increasingly used in preclinical research and may influence future testing paradigms.