OffTargetAktivitäten
OffTargetAktivitäten, often translated as off-target effects or off-target activities, refers to unintended consequences or biological actions of a therapeutic agent that are not related to its primary intended mechanism of action. This phenomenon is particularly relevant in the development of drugs and gene therapies. When a drug targets a specific molecule or pathway to achieve a therapeutic effect, it may also interact with other molecules or pathways in the body, leading to side effects or unexpected outcomes.
The identification and mitigation of OffTargetAktivitäten are crucial steps in drug discovery and development. Researchers employ
In gene therapy, OffTargetAktivitäten specifically relate to the unintended modification or expression of genes at sites