Nukleofilin

Nukleofilin is not a term that corresponds to a widely recognized molecule or protein in standard scientific references. In many cases, it appears to be a misspelling or transliteration of other terms, such as nucleophile in chemistry or the name of a nuclear protein in non-English literature. Because of this ambiguity, there is no single, authoritative definition or description for a distinct entity routinely labeled “nukleofilin.”

In chemistry, a nucleophile (from Latin nucleus and Greek philos meaning “nucleus-loving”) is a species that donates an electron pair to an electrophile, forming a chemical bond. Nucleophilicity depends on factors such as charge, electronegativity, solvent, and steric hindrance. Common nucleophiles include hydroxide, amines, alkoxides, and thiolates. They participate in reactions such as nucleophilic substitution (SN1 or SN2) and nucleophilic additions to carbonyl compounds. The strength and behavior of a nucleophile are influenced by the solvent environment; for example, polar aprotic solvents often enhance nucleophilicity of charged species.

In biology or medicine, if the term appears in non-English texts, it may be a mistaken reference to nucleolin, nucleophosmin, or another nuclear-associated protein, rather than a distinct, widely recognized factor named “nukleofilin.” Without clear, citable sources, it is prudent to treat the term as ambiguous and verify the intended meaning from the original publication or language.

See also: nucleophile, nucleophilicity, SN2 reactions, nucleophilic addition.