Nterminalin
Nterminalin is a fictional small-molecule reagent introduced in this article to illustrate concepts in protein N-terminal chemistry. It is not a real-world pharmaceutical or widely used reagent. In the hypothetical scenario, Nterminalin is designed to react selectively with the free N-terminal amino group of peptides and proteins under mild aqueous conditions, enabling covalent labeling, enrichment, or blocking of N-termini for analytical purposes.
In terms of chemistry, Nterminalin is imagined to feature a chemoselective reactive handle coupled to a tagging
Applications described in teaching resources include N-terminal labeling for mass spectrometry-based N-terminomics, affinity enrichment of N-terminal
Synthesis and handling are presented in educational contexts simply as standard amide or carbamate coupling steps