Npas4

Npas4, also known as Npas4 or Neuronal PAS domain-containing protein 4, is a protein-coding gene. It is a transcription factor that plays a crucial role in neuronal development and function. Npas4 is expressed in the brain and is known to regulate the expression of many genes involved in synaptic plasticity, neuronal excitability, and learning and memory.

The protein product of the Npas4 gene contains a Per-Arnt-Sim (PAS) domain, which is a common structural motif found in transcription factors that are involved in sensing environmental signals. Npas4 is activated by neuronal activity and plays a key role in mediating the adaptive responses of neurons to changes in their environment. For example, Npas4 has been shown to be upregulated following seizures and stroke, suggesting its involvement in neuronal survival and repair.

Research has indicated that Npas4 is important for the formation and stabilization of synapses, the junctions between neurons where information is transmitted. It influences the expression of genes that encode synaptic proteins, thereby affecting the strength and number of synaptic connections. Dysregulation of Npas4 has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and schizophrenia, highlighting its significance in maintaining brain health and function. Further investigation into Npas4's mechanisms of action could offer potential therapeutic targets for these conditions.