Noncodeleted

Noncodeleted is an adjective used in genetics to describe a sample in which a predefined chromosomal deletion or gene loss has not occurred. It serves as the opposite status to codeleted, where the same region shows simultaneous deletion. The term is most often encountered in discussions of copy-number variation in tumors or other genomic contexts.

In oncogenetics, codeletion such as the loss of chromosomal arms may define a molecular subtype with specific clinical features. A noncodeleted sample lacks such deletions and may belong to a different genetically defined subgroup, with potential implications for prognosis and therapeutic choice. The precise locus and thresholds depend on the study design, and not all literature uses identical definitions of noncodeleted.

Detection and confirmation are typically achieved through methods that measure copy number, including fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH) arrays, SNP arrays, and sequencing-based approaches. Consistency in nomenclature and reporting is important to ensure comparability across studies.

Etymology and usage: The term appears as noncodeleted or non-codeleted, formed by the English negative prefix non- and codeletion. It is not widely standardized and is more common in small-scale reports or methodological notes than in formal nomenclature.

See also: codeletion, copy-number variation, 1p/19q codeletion.