Nnitrosodietyyliamiini

Nnitrosodietyyliamiini, more commonly known as N-nitrosodiethylamine (NDEA), is a chemical compound in the nitrosamine family. It is formed by nitrosation of diethylamine or related secondary amines, typically under acidic conditions. The molecule features two ethyl groups bonded to a nitrogen atom that is also bonded to a nitroso group (N-N=O), giving it the characteristic nitrosamine structure.

NDEA is a volatile, colorless to pale-yellow liquid that is soluble in many organic solvents and miscible with some aqueous systems. It is primarily of interest as a toxicological and regulatory concern rather than for routine industrial use. The compound is considered a potent carcinogen in multiple animal species and is classified as a probable human carcinogen by international health agencies. Exposure can occur through tobacco smoke, certain cured or processed foods where nitrite curing agents are used, contaminated drinking water, and some occupational settings. Its carcinogenicity is linked to metabolic activation in the liver, where enzymes such as cytochrome P450 generate reactive intermediates that can alkylate DNA and cause mutations.

In practice, N-nitrosodiethylamine is mainly encountered in toxicology research and as a reference compound for studying nitrosamine formation and DNA damage. Regulatory and health agencies emphasize minimizing nitrosamine formation in foods and consumer products and controlling occupational exposure. Safe handling in laboratories and appropriate containment are required due to its carcinogenic potential.