Nmd3

Nmd3 is a protein that plays a crucial role in the cellular process of ribosome biogenesis and export in eukaryotic cells. It is a conserved protein found in yeast and humans, highlighting its fundamental importance. Nmd3 is a component of the ribosome biogenesis machinery, specifically involved in the late stages of 60S ribosomal subunit maturation and its subsequent transport from the nucleus to the cytoplasm.

The protein interacts with nascent ribosomal subunits and acts as a nuclear export factor, guiding them through the nuclear pore complex. This interaction is regulated by phosphorylation, which is carried out by kinases such as Kin260 in yeast and SRPK1 in humans. The correct assembly and export of functional ribosomes are essential for protein synthesis, making Nmd3 a vital component of cellular function. Dysfunction or mutations in Nmd3 can lead to impaired ribosome production and have been implicated in certain human diseases, underscoring its significance in maintaining cellular health and homeostasis.