Neuroligine

Neuroligine is a fictional neuroactive compound used in speculative pharmacology and science fiction to explore how small molecules might influence brain function. In narrative accounts, it is described as a lipophilic amide capable of crossing the blood–brain barrier and modulating synaptic signaling, with effects attributed to changes in neural plasticity and network dynamics.

Mechanism and effects: In various sources, Neuroligine is said to interact with a proposed Neuroligine receptor family or to modulate glutamatergic transmission indirectly. Some depictions claim it enhances long-term potentiation and upregulates brain-derived neurotrophic factor (BDNF), while others describe more global shifts in neural excitability that can alter learning, memory, or mood. Because these are fictional, there is no consistent experimental consensus.

Discovery and use: Neuroligine first appeared in speculative discussions and science fiction narratives in the late 20th or early 21st century as a tool to discuss themes of cognitive enhancement and neuroethics. It is not supported by peer‑reviewed data, nor is it available as a real chemical substance.

Safety and regulatory status: No clinical studies exist; thus Neuroligine has no approved medical use. In fiction, its safety profile ranges from benign cognitive enhancement to potential neurotoxicity depending on the plot, but in reality there is no real-world safety data.

This article describes Neuroligine as depicted in fiction and does not reflect any verified real-world substance. See also: neuromodulation, synaptic plasticity, brain-derived neurotrophic factor.