Neurokinin3

Neurokinin3 is a receptor for the neurokinin B peptide, which is part of the tachykinin family of neuropeptides. It is a G protein-coupled receptor, meaning it functions by transmitting signals from outside the cell to the inside through a G protein.

The neurokinin3 receptor is a specific subtype of tachykinin receptors, which also include neurokinin1 and neurokinin2 receptors. These receptors are responsible for mediating the physiological effects of their respective peptides in various systems of the body, including the nervous system and the cardiovascular system.

The neurokinin3 receptor is involved in regulating the gonadotropin-releasing hormone (GnRH) pulse generator, which plays a key role in the endocrine system. Activation of this receptor by neurokinin B can stimulate the release of GnRH, which in turn controls the secretion of other hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Neurokinin3 receptors are found in various tissues including the pituitary gland, the hypothalamus, and the roots of the vagus nerve. Research has shown that they are involved in various physiological and pathological processes including anxiety, stress response, and the regulation of immune function.

Mutations in the gene that codes for the neurokinin3 receptor have been linked to various conditions, including reduced fertility and dysregulation of the reproductive axis. Studies of the neurokinin3 receptor have contributed to our understanding of the role of neuropeptides in disease and has led to the development of therapeutic strategies for treating related conditions.