Nasonex

Nasonex is the brand name for mometasone furoate nasal spray, an intranasal corticosteroid used to treat nasal inflammation. It works by reducing the activity of multiple inflammatory mediators, leading to decreased edema, mucus production, nasal itching, sneezing, and congestion.

Indications include relief of symptoms of seasonal and perennial allergic rhinitis in adults and children, prevention of nasal polyps after surgery, and adjunctive treatment of nasal polyps in some markets. It is not intended for treating acute bacterial infections of the nose.

Administration and dosing typically involve a metered-dose nasal spray. Regimens commonly include one spray per nostril daily for children aged 2–11 and two sprays per nostril daily for adults, with adjustments guided by a clinician. Proper priming before first use and correct aiming away from the eyes are recommended. Regular, ongoing use provides best symptom control.

Common side effects include nasal irritation or burning, nosebleeds, sneezing, sore throat, headache, and cough. Rare but possible systemic corticosteroid effects can occur at high doses, including suppression of the hypothalamic-pituitary-adrenal axis and potential growth effects in children with prolonged use. Cautions include avoiding use in the presence of untreated nasal fungal infections, and consideration of underlying nasal or sinus conditions.

Contraindications include hypersensitivity to mometasone or any components of the formulation. Potential drug interactions are limited due to low systemic absorption, but strong CYP3A4 inhibitors may increase systemic exposure in rare cases.

Pregnancy and lactation require a risk-benefit assessment; use during pregnancy should be limited to cases where benefits justify potential risks, and breastfeeding should be discussed with a clinician. Nasonex is a prescription medication in many countries, with generic mometasone furoate nasal spray available in some markets.