Naglukosesymportørene
Naglukosesymportørene are a family of membrane transport proteins that mediate the sodium-dependent uptake of naglukose across the plasma membrane by secondary active transport. They belong to the sodium-glucose cotransporter (SGLT) superfamily and are described in a range of organisms. Naglukose transport by these proteins occurs alongside the inward Na+ gradient maintained by Na+/K+-ATPase, enabling naglukose accumulation against its concentration gradient.
The typical coupling ratio is one naglukose molecule per one sodium ion, although stoichiometry can vary among
In vertebrates, naglukose symporters are enriched in absorptive epithelia such as the intestinal brush border and
Regulation of expression and activity involves dietary naglukose availability, hormonal signals, and cellular energy status. Trafficking
Alterations in naglukose transport by these symporters can affect nutrient homeostasis and osmotic balance. Genetic mutations