Naftin

Naftin is the brand name for naftifine hydrochloride, a topical antifungal medication used to treat superficial fungal infections of the skin. It belongs to the allylamine class and works by inhibiting the fungal enzyme squalene epoxidase, a key step in ergosterol synthesis. Inhibition leads to accumulation of squalene and disruption of the fungal cell membrane, producing antifungal activity against dermatophytes and some yeasts.

Indications include athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). It may also be used for other superficial fungal infections as directed by a clinician.

Administration and dosage involve applying Naftin topically to the affected area, typically twice daily for about one to two weeks, with longer treatment sometimes needed for more extensive infections or slower response. The medication should be applied to clean, dry skin and continued for the full prescribed course even if symptoms improve.

Adverse effects are usually local and mild, with the most common being skin irritation at the application site, such as burning, itching, redness, or stinging. Less commonly, contact dermatitis or allergic reactions can occur.

Pharmacology and pharmacokinetics indicate minimal systemic absorption after topical application, so systemic adverse effects and interactions are unlikely. Use with caution on damaged skin or in patients with known hypersensitivity.

Regulatory status: In many countries, Naftin is available by prescription as a 1% topical cream; availability may vary by region. See also antifungal agents and allylamines.