NXF1TAP
NXF1TAP, commonly referred to as TAP (nuclear export factor 1), is a central component of the eukaryotic mRNA export machinery. In vertebrates it acts as the principal receptor that mediates the export of mRNA from the nucleus to the cytoplasm. NXF1 forms a heterodimer with the small partner NXT1 (p15), and together they ferry mRNA through the nuclear pore complex.
Mechanism: The NXF1–NXT1 complex associates with mRNA via export cofactors and adapters such as Aly/REF and
Structure and evolution: NXF1 is a modular protein with regions that mediate RNA binding, protein interactions,
Clinical and research relevance: NXF1/TAP is essential for cellular viability; depletion or dysfunction leads to nuclear