NME2

NME2, also known as Nucleoside Diphosphate Kinase 2, is a protein-coding gene found in humans. This gene encodes a subunit of nucleoside diphosphate kinase, an enzyme that plays a crucial role in cellular metabolism. Specifically, nucleoside diphosphate kinase catalyzes the transfer of a phosphate group from nucleoside triphosphates (like ATP) to nucleoside diphosphates (like GDP, CDP, UDP, and ADP). This reaction is vital for maintaining the cellular pool of nucleoside triphosphates, which are essential building blocks for DNA and RNA synthesis, as well as for energy currency in various cellular processes.

The NME2 gene is part of a family of related genes, including NME1 and NME3, which share structural and functional similarities. While the exact specific functions of each NME gene may differ slightly, they generally contribute to nucleotide metabolism. Research has indicated that NME2 may also be involved in processes beyond direct nucleotide phosphorylation, with potential roles in cell proliferation, differentiation, and even tumor suppression. Mutations or alterations in NME2 expression have been implicated in certain diseases, suggesting its importance in maintaining cellular homeostasis. The protein product of NME2 is found in various cellular compartments, including the cytoplasm and nucleus.