Multicellularlike

Multicellularlike refers to traits or organizational forms in biology that resemble multicellularity—where many cells cooperate, differentiate, and coordinate development—while not always satisfying formal definitions of true multicellularity. The term is used to discuss transitional states, transient aggregations, and model systems that exhibit division of labor and integrated function without permanently differentiated tissues.

Examples include social and colonial systems such as Dictyostelium discoideum, which aggregates into a multicellular slug and develops into a fruiting body under starvation, and Volvox carteri, a green alga whose somatic cells perform locomotion and the reproductive cells produce new colonies. Biofilms and some cyanobacterial colonies also show coordinated behavior, resource sharing, and spatial organization that resembles multicellular cooperation, though they may lack a fully integrated developmental program. These cases illuminate possible evolutionary steps toward true multicellularity.

Key features associated with multicellularlike organization include cellular adhesion and signaling, division of labor, programmed cell death contributing to development, and some form of developmental regulation. However, many such systems lack permanent tissue differentiation, a comprehensive organismal genome-wide regulatory network, or irreversible commitment to a developmental plan.

Understanding multicellularlike states informs studies of the evolution of multicellularity, tissue organization, and cooperative behavior, and has implications for synthetic biology and the design of cooperative microbial communities.