MrMs

MRMs is an acronym used in multiple fields, and its meaning depends on the context. The most widely used sense in analytical chemistry and proteomics is Multiple Reaction Monitoring, a targeted mass spectrometry approach for quantitative measurement of specific molecules.

Multiple Reaction Monitoring involves a tandem mass spectrometer, often a triple quadrupole instrument, configured to monitor selected precursor-to-product ion transitions. By focusing on predefined transitions, MRMs achieve high selectivity and sensitivity in complex samples. Quantitation is typically done with stable isotope-labeled internal standards, allowing compensation for ion suppression and variable sample processing. The method can quantify dozens of analytes in a single run, with a wide dynamic range.

Developing an MRM assay includes peptide or metabolite selection, transition optimization, collision energy tuning, and retention-time scheduling on the instrument. It is widely used in clinical proteomics, pharmacokinetics, and biomarker validation, as well as food safety and environmental testing. Limitations include the need for prior knowledge of targets, potential interference from isobaric species, and the time required for method development and validation.

In finance and risk management, MRMs can refer to Model Risk Management—the governance and control framework for the development, validation, and monitoring of mathematical models used in risk assessment. In manufacturing contexts, MRMs may denote Materials Requirements Management or similar material-planning functions within ERP systems, though this usage is less standardized.

Because MRMs has multiple meanings, it is important to determine the field and specific context to interpret the term correctly.