Milligramformilligram

Milligramformilligram is a coined term used in pharmacology and related fields to describe a direct, one-to-one comparison of quantities between two substances at the milligram scale. It denotes an attempt to express that the masses of active material in two preparations are equal on a mg-for-mg basis, without implying any claim about potency, bioavailability, or therapeutic equivalence.

In practice, milligramformilligram is often invoked when discussing dosage equality between formulations or generic and brand-name products. It is commonly used to indicate that a tablet or solution contains the same amount of the active ingredient as another reference product, measured precisely in milligrams. However, this concept does not address differences in pharmacokinetics, absorption, metabolism, or clinical effect, all of which can produce different real-world outcomes despite equal milligram content.

Limitations and caution are important: milligramformilligram is not a substitute for formal bioequivalence or therapeutic equivalence assessments. Salt forms, polymorphs, excipients, and manufacturing processes can alter distribution and action even when the active drug mass matches.

Origin of the term is informal, arising in discussions about dose calculations or regulatory labeling, and it has no official standing in international pharmacopoeias. See also bioequivalence, pharmacokinetics, and dosage form equivalence.