Microperfusie

Microperfusie is a technique used in scientific research and clinical settings to deliver small volumes of fluids to specific locations, often within biological tissues or organs. This controlled delivery method allows for precise application of substances such as drugs, growth factors, or imaging agents, minimizing systemic exposure and maximizing local concentration. The term "micro" refers to the very small quantities of fluid being administered, typically in the range of microliters or nanoliters. "Perfusie" relates to the process of passing a fluid through a tissue or organ.

The application of microperfusie varies widely. In research, it can be used to study the localized effects of a substance on cells or tissues, to perfuse isolated organs for transplantation studies, or to deliver experimental therapies directly to a tumor site. Clinically, microperfusie principles are employed in certain drug delivery systems, such as localized chemotherapy, or in diagnostic procedures where contrast agents are precisely introduced. The technology often involves specialized pumps, microfluidic devices, or fine needles to achieve the desired accuracy and control. Challenges in microperfusie include ensuring consistent flow rates, preventing clogging, and accurately targeting the desired microenvironment. Despite these challenges, microperfusie offers a powerful tool for highly targeted interventions in both research and medicine.