Microinhalation

Microinhalation refers to the introduction of very small quantities of a substance into the respiratory system, typically the lungs, through a fine aerosol or spray. This method is distinct from traditional nebulization which often produces larger droplet sizes and less controlled delivery. The primary goal of microinhalation is to precisely deliver therapeutic agents directly to the airways or the deep lung for localized treatment or systemic absorption. This technique is particularly relevant in the development of new drug delivery systems for respiratory diseases such as asthma, COPD, and cystic fibrosis. The small particle size achieved with microinhalation allows for deeper penetration into the smaller airways and alveoli, potentially enhancing drug efficacy and reducing systemic side effects. Devices designed for microinhalation often employ specialized technologies like ultrasonic nebulizers, vibrating mesh nebulizers, or metered-dose inhalers with advanced actuation mechanisms to generate and control the extremely fine droplets required. Research in this area focuses on optimizing particle size distribution, inspiratory flow rates, and device design to ensure efficient and targeted drug deposition in the lungs.