Mannichi
The Mannich reaction, also known as the aminomethylation reaction, is a fundamental organic synthesis process named after the German chemist Carl Mannich. This reaction involves the formation of a β-aminocarbonyl compound by reacting an active methylene compound (such as a ketone or aldehyde) with formaldehyde and a primary or secondary amine in the presence of an acid catalyst. The product is commonly referred to as a Mannich base.
The reaction typically proceeds through a nucleophilic addition mechanism. The amine reacts with formaldehyde to generate
Key features of the Mannich reaction include its ability to introduce an aminomethyl group onto various substrates,
Despite its utility, the Mannich reaction has some limitations, including potential side reactions such as polymerization