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MRI contrast agents are substances administered to patients undergoing magnetic resonance imaging (MRI) to enhance the visibility of specific tissues or blood vessels. These agents work by altering the magnetic properties of nearby water molecules, which are abundant in the body. This alteration leads to changes in the signal intensity on MRI scans, making certain structures appear brighter or darker than they would without the contrast agent. The most common type of MRI contrast agent contains gadolinium, a rare earth metal. When administered, these agents can accumulate in areas with increased blood flow or breakdown of the blood-brain barrier, such as tumors or sites of inflammation. This allows radiologists to better delineate the extent of disease and identify abnormalities that might otherwise be missed. Other types of contrast agents exist, including iron-based agents and those that target specific molecules or cell types. The administration of contrast agents is typically done intravenously. While generally safe, potential side effects can occur, ranging from mild reactions like nausea or headache to rarer, more serious complications such as allergic reactions or nephrogenic systemic fibrosis in individuals with severe kidney disease. Before undergoing an MRI with contrast, patients are usually screened for allergies and kidney function.