MMPmediated
MMP-mediated refers to biological processes driven by matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and other extracellular substrates. MMPs are synthesized as inactive proenzymes and become active through proteolytic removal of their propeptide. Their activity is tightly controlled by tissue inhibitors of metalloproteinases (TIMPs) and by their cellular localization and activation status.
In physiology, MMP-mediated remodeling supports embryonic development, wound repair, angiogenesis, and tissue turnover. In pathology, aberrant
MMP substrates extend beyond structural ECM proteins such as collagens, gelatin, laminin, and proteoglycans to include
Regulation of MMP-mediated processes involves transcriptional control, zymogen activation, TIMP-mediated inhibition, and spatial confinement within tissue