MBP1

MBP1 is an acronym used for different proteins in different organisms, with two of the best studied being MBP1 in budding yeast and MBP-1 in humans. The human term MBP-1 is sometimes used interchangeably with AATF (apoptosis antagonizing transcription factor), reflecting historical names for the same protein. In all cases, the name denotes a transcription-related protein that interacts with other regulatory factors, but the exact function can vary by organism and context.

In Saccharomyces cerevisiae, MBP1 encodes a DNA-binding protein that forms a transcriptional regulatory complex with Swi6. This MBF (MluI cell cycle box-binding factor) complex binds to MCB elements in promoters of genes required for DNA replication and S-phase progression. MBP1 contributes to the activation of these G1/S and S-phase genes, helping to coordinate the cell cycle. The activity of MBP1 is modulated by cell cycle signals and other regulatory inputs, and defects in MBP1 or MBF can lead to delayed entry into S phase and impaired DNA replication gene expression.

In humans, MBP-1 traditionally refers to Myb-binding protein 1, now commonly discussed under the alias AATF (apoptosis antagonizing transcription factor). MBP-1/AATF is a nuclear transcription factor that can interact with Myb family proteins and other regulators. It has been implicated in processes related to cell proliferation and apoptosis and is studied for its potential involvement in p53-regulated pathways and cancer biology. The precise role of MBP-1/AATF appears to be context-dependent, with different studies reporting varied effects on gene expression and cell fate.

Because MBP1 is an acronym used for multiple proteins, readers should note the species and gene context when consulting literature.