Liverproduced

Liverproduced refers to substances that originate predominantly from hepatocytes in the liver. These compounds are essential for maintaining blood composition, digestion, metabolism, and overall systemic homeostasis. While the liver produces a wide range of molecules, in common usage it highlights products synthesized directly by hepatic cells rather than acquired from the diet or produced elsewhere in the body.

Examples of liverproduced substances include plasma proteins such as albumin and several coagulation factors (for example, factors II, VII, IX, and X, as well as fibrinogen). The liver also makes transport and regulatory proteins like transferrin, transthyretin, and various acute-phase proteins such as C-reactive protein, serum amyloid A, and hepcidin. Immune and complement components produced by the liver contribute to defense and inflammation. In metabolic pathways, the liver generates hormones and growth factors such as insulin-like growth factor 1 (IGF-1), as well as components involved in lipid and cholesterol homeostasis, including bile acids (cholic and chenodeoxycholic acid) and lipoproteins like VLDL, LDL, and HDL.

Functions of liverproduced substances are diverse. They help maintain blood volume and pressure through albumin, enable blood clotting through coagulation factors, transport lipids and minerals, form bile for fat digestion, regulate cholesterol metabolism, and participate in detoxification and endocrine signaling. They also respond to inflammation by altering the production of certain proteins.

Clinical relevance centers on hepatic synthetic capacity. Reduced production can lead to hypoalbuminemia and coagulopathy, while altered levels of acute-phase proteins, iron-regulating hormones like hepcidin, or lipoproteins can indicate liver dysfunction or inflammatory states. Liver function tests often assess these synthetic outputs alongside other biomarkers.