Lisch

Lisch may refer to more than one use, including a surname of German origin and a medical sign associated with neurofibromatosis type 1 (NF1).

As a surname, Lisch is of German origin and is found in German-speaking regions as well as among descendants worldwide.

In medical contexts, Lisch nodules are iris hamartomas commonly found in NF1. They appear as small, pigmented, dome-shaped lesions on the iris and are typically detected through slit-lamp examination. Lisch nodules usually emerge in childhood or adolescence and increase in number with age. They do not typically affect visual acuity but are a useful diagnostic feature for NF1. NF1 is an autosomal dominant genetic disorder caused by pathogenic variants in the NF1 gene on chromosome 17 and is characterized by a variety of clinical features, including café-au-lait spots, neurofibromas, axillary or inguinal freckling, and other manifestations. The NIH diagnostic criteria for NF1 require two or more of the following: six or more café-au-lait macules, two or more neurofibromas or one plexiform neurofibroma, freckling in the axillary or inguinal regions, optic glioma, two or more Lisch nodules, distinctive osseous lesions, and a first-degree relative with NF1. Management focuses on surveillance for complications and treatment of specific symptoms. Lisch nodules themselves are benign indicators and do not necessitate treatment unless considered within the broader context of NF1 monitoring.