Liposomeilla

Liposomeilla is a term used in nanomedicine to describe a class of lipid-based vesicular carriers derived from conventional liposomes but engineered with features intended to improve stability, circulation time, and targeting.

Structurally, liposomeilla are spherical vesicles with an aqueous core surrounded by a phospholipid bilayer, often reinforced with cholesterol or crosslinkable lipids. A surface layer, such as polyethylene glycol, can create a stealth corona, and targeting ligands may be attached to promote receptor-mediated uptake.

They can encapsulate hydrophilic cargo in the core and hydrophobic cargo within the bilayer. Release properties are tuned by lipid composition, cholesterol fraction, and crosslinking, while surface modifications influence stability in blood and interactions with the immune system.

Production typically uses thin-film hydration followed by extrusion or microfluidic methods. Common lipid components include phosphatidylcholine, cholesterol, sphingomyelin, and PEG-lipids; formulation is assessed by size distribution, zeta potential, morphology by electron microscopy, and encapsulation efficiency.

Applications under investigation include anticancer drug delivery, gene delivery, and multimodal imaging. Advantages include biocompatibility and customizable pharmacokinetics; challenges cover reproducibility, scale-up, stability during storage, and potential immunogenic responses.

The term liposomeilla is not widely standardized and appears mainly in exploratory literature. It should be distinguished from conventional liposomes and other lipid nanoparticles, as usage varies among researchers and may reflect specific design features.