Lewybody
Lewy bodies are abnormal intracellular protein aggregates found within neurons. They are eosinophilic inclusions composed mainly of misfolded alpha-synuclein, along with other proteins such as ubiquitin. Lewy bodies were first described by Friedrich Lewy in 1912 as distinctive inclusions in the brainstem neurons of people with Parkinson's disease. They are the pathological hallmark of Lewy body diseases, a group that includes Parkinson's disease (PD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD).
In Parkinson's disease, Lewy bodies are most dense in the brainstem regions such as the substantia nigra,
Diagnosis is typically clinical, supported by imaging and biomarkers, with definitive confirmation requiring postmortem neuropathological examination.