LSm17s

LSm17s is a member of the LSm family of Sm-like RNA-binding proteins found in eukaryotes. As with other LSm proteins, LSm17s is presumed to participate in RNA metabolism by forming part of ring-shaped complexes that interact with target RNAs.

Function: The exact role of LSm17s is under investigation; based on homology to canonical LSm subunits, it is thought to contribute to cytoplasmic mRNA decay through the LSm1-7 complex and to participate in nuclear RNA processing as part of the LSm2-8 assembly. It binds U-rich RNA sequences and is associated with RNA turnover factors and spliceosomal components in model systems.

Structure and localization: LSm17s is a small protein containing an Sm-like domain and is predicted to assemble with other LSm partners to form oligomeric rings. Localization studies in related species place LSm proteins in cytoplasmic processing bodies and in the nucleus, with LSm1-7 favoring cytoplasmic mRNA decay and LSm2-8 functioning in splicing; LSm17s is thought to display overlapping distribution, depending on tissue and condition.

Evolution and orthology: The LSm family is highly conserved across eukaryotes, with orthologs spanning yeast, plants, and animals. LSm17s is typically encoded by a single gene and shows sequence similarity to other Sm-like proteins.

Status and references: As a relatively recent or organism-specific member, detailed biochemical characterizations and physiological roles for LSm17s remain limited; ongoing studies aim to clarify its precise partners, RNA substrates, and impact on gene expression.