LILRB124

LILRB124, also known as Leucine-rich repeat-containing protein 124, is a protein that in humans is encoded by the LILRB1 gene. This gene is a member of the leucine-rich repeat (LRR) gene family, which is involved in various biological processes including immune response, cell adhesion, and signal transduction.

The LILRB1 gene is located on chromosome 19 and consists of 11 exons. It encodes a protein with a signal peptide, a propeptide, and a mature peptide region. The mature peptide region contains 124 leucine-rich repeats, which are characteristic of the LRR family. These repeats are thought to play a role in protein-protein interactions, which are crucial for the function of LILRB1.

The exact function of LILRB124 is not fully understood, but it is believed to be involved in immune response and inflammation. Some studies suggest that LILRB124 may interact with other immune-related proteins, such as Toll-like receptors, and play a role in the regulation of the immune system. Additionally, there is evidence that LILRB124 may be involved in the development of certain diseases, including autoimmune disorders and cancer.

Mutations in the LILRB1 gene have been associated with various diseases, including familial Mediterranean fever (FMF), a genetic disorder characterized by recurrent episodes of fever and inflammation. FMF is caused by mutations in the MEFV gene, which encodes a protein that interacts with LILRB124. This interaction is thought to play a role in the development of FMF.

In summary, LILRB124 is a leucine-rich repeat-containing protein that plays a role in immune response and inflammation. Its exact function is not fully understood, but it is believed to interact with other immune-related proteins and play a role in the development of certain diseases. Mutations in the LILRB1 gene have been associated with familial Mediterranean fever. Further research is needed to fully understand the role of LILRB124 in health and disease.