LDLRbinding
LDLRbinding refers to the interaction between the low-density lipoprotein receptor (LDLR) and its ligands, primarily low-density lipoprotein (LDL). This process is critical for cellular cholesterol homeostasis and plays a significant role in lipid metabolism. The LDLR is a transmembrane protein expressed primarily in the liver, where it facilitates the endocytosis of LDL particles, enabling the uptake of cholesterol for cellular use or storage.
The binding of LDL to the LDLR occurs via the apolipoprotein B-100 (ApoB-100) component of LDL, which
Mutations or dysfunctions in the LDLR or its ligands can lead to impaired cholesterol regulation, contributing
Research into LDLR binding also explores potential treatments for other lipid-related disorders, such as homozygous FH,